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  "Title": "Monitoring Overall Survival in Pivotal Trials in Indolent\nCancers",
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  "Description": "These guidelines are meant to provide a pragmatic, yet\nrigorous, help to drug developers and decision makers, since\nthey are shaped by three fundamental ingredients: the\nclinically determined margin of detriment on OS that is\nunacceptably high (delta null); the benefit on OS that is\nplausible given the mechanism of action of the novel\nintervention (delta alt); and the quantity of information (i.e.\nsurvival events) it is feasible to accrue given the clinical\nand drug development setting. The proposed guidelines\nfacilitate transparent discussions between stakeholders\nfocusing on the risks of erroneous decisions and what might be\nan acceptable trade-off between power and the false positive\nerror rate.",
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